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KMID : 0923620130130060249
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Immune Network
2013 Volume.13 No. 6 p.249 ~ p.256
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IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses
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Kim So-Hee
Karasuyama Hajime
Lopez Angel F.
Ouyang Wenjun
Li Xiaoxia
Gros Graham Le
Min Boo-Ki
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Abstract
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How Th2 immunity develops in vivo remains obscure. Basophils have been considered key innate cells producing IL-4, a cytokine essential for Th2 immunity. Increasing evi-dence suggests that basophils are dispensable for the ini-tiation of Th2 immunity. In this study, we revisited the role of basophils in Th2 immune responses induced by various types of adjuvants. Mice deficient in IL-3 or IL-3 receptor, in which basophil lymph node recruitment is completely abolished, fully developed wild type level Th2 CD4 T cell responses in response to parasite antigen or papain immunization. Similar finding was also observed in mice where basophils are in-ducibly ablated. Interestingly, IL-4-derived from non-T cells appeared to be critical for the generation of IL-4-producing CD4 T cells. Other Th2 promoting factors including IL-25 and thymic stromal lymphopoietin (TSLP) were dispensable. Therefore, our results suggest that IL-3- and basophil-in-dependent in vivo Th2 immunity develops with the help of non-T cell-derived IL-4, offering an additional mechanism by which Th2 type immune responses arise in vivo.
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KEYWORD
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Basophils, Papain, Parasites, Th2 immunity
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